about Nutri Genomic


This genetic metabolic screen assesses how your genes may impactspecific metabolic processes that have a bearing on your overallhealth.

The way we fuel our bodies with the foods we eat are all impacted by our genetic make-up. The old adage “you are what you eat” plays a major role in determining our health and wellbeing. Food and its utrients directly and indirectly influence our gene expressions. Genetic variations affecting certain metabolic traits in turn dictates dietary needs and requirements for instance, the response to food varies from individual to individual explaining why some people can eat as much as they want and never gain weight. These factors may be attributed to the large role that genes play in influencing eating behaviors and metabolism of different foods. 

We have assessed your genes more than 50 metabolic traits for which we have arrived at tailor-made dietary recommendations. Your nutrient requirements are formulated to suit the genetic variations identified in your DNA. Your results have been analyzed to determine the best diet likely to help you optimize your health, stay fit and feel happier! 

What We Covered:


Though most of us think of aspects such as choice, quantity and frequency of food as voluntary, hormones play a significant role in these choices. Hormones are in-turn regulated by genes. Individuals with certain genotypes have been observed to experience difficulty in feeling full, tend to eat more without feeling satisfied, snack frequently and tend to crave for energy dense foods high in sugars and fats. About 70% of overweight people have low satiety trait and people with low satiety eat 10% more calories per meal than people with normal satiety.

 

Human tongue has millions of taste receptors which allow us to taste the various foods. Genetic differences, manifested as variations in taste receptors from person to person, explain the individual food preferences and impact eating behavior and nutritional intake. Food preferences are influenced by environmental factors, cultural factors, availability and also by genetic characteristics. For example, people who are classified as supertasters, genetically, are averse to chemicals in cruciferous vegetables. Some people are less sensitive to sugar leading them to overconsume. Generally, the less sensitive one is, the more they will consume that foods.

 
  • Dietary proteins provide amino acids for the synthesis of body proteins, active enzymes and other biologically important nitrogenous compounds in the body. High protein diets, particularly in individuals with certain genotypes can have beneficial effect on weight maintenance.
  • As per the IMRB survey, 9 out 10 Indians are consuming inadequate amounts of protein. Higher number of vegetarians (91%) show a protein deficit as compared to nonvegetarians (85%).
  • Protein deficiency could be attributed to poor muscle mass, higher triglyceride levels and higher prevalence of central adiposity among Indians. By modulating your protein intake according to your genotype can help address the above mentioned conditions and help maintain optimal body weight.
 
  • Dietary fibre is essential to maintaining body weight and composition, blood sugar, triglycerides and cholesterol.
  • Individuals respond differently to their dietary fibre intakes. However, adequate dietary fibre intakes have beneficial effects on waist circumference and BMI in individuals with certain genotypes.
  • With economic and dietary transition that has taken place in India as a result of globalization, more and more proportion of people are shifting to processed, refined and packaged foods. Therefore, dietary fibre is acquiring greater significance due to its beneficial role in maintenance of optimal body weight and the associated health benefits.
 
  • Genes influences an individuals’ tendency to gain weight back after losing weight and there are some genes that have protective effect from weight regain.
  • Adiponectin is a hormone that is produced by the fat cells and is involved in the utilization of fat to obtain energy. Higher adiponectin levels are considered beneficial for weight loss and health. Genetic variations influence the adiponectin levels in our body.
  • Individuals with certain genotypes are more likely to gain weight back, while others are more likely to maintain the weight loss. It is therefore best after losing weight to maintain a healthy diet, exercise and nutrition plan to maintain the weight loss and support long term health.
 

Carbohydrates provide the main source of energy for the body. However, excess consumption, particularly in individuals with certain genotypes can lead to excess weight gain, diabetes and other conditions. The current Indian diet is significantly higher in refined carbohydrates and lower in protei. As a consequence, obesity, diabetes and heart disease rates are very high in India. By modifying your carbohydrate consumption according to your genotype you can maintain a healthy and balanced weight.

 

Individuals with certain genotypes may have higher levels of LDL cholesterol and more prone to weight gain in response to high levels of saturated fat in their diet. Such individuals may benefit from limiting saturated fat intake. Replacing both saturated and trans fats with unsaturated (Poly & Mono unsaturated) fats helps to improve cholesterol levels, insulin sensitivity and BMI.

 

In this we are doing assessment of your genes which are responsible for vitamins, any defeact in this genotype may lead to deficiency of vitamins which are lead to produces some serious disease in future or may lead to transfer in child also. In this, these all vitamins never screening by blood reports in routines.

 

Iron is an essential mineral that actively takes part in oxygen transport through blood (bound to proteins like hemoglobin in RBC & myoglobin in muscle). According to the International Institute of Population Studies, prevalence of anaemia is very high among children (>95%), pregnant women (96.2 %) and adolescent girls (97.8%) in India, which translates to higher incidence of infections and illness in the country. Individuals with certain genotypes have reduced ability to absorb iron from the diet, regulating hepcidin levels and increasing dietary sources of iron can be beneficial.

 

Calcium is the most abundant mineral in the human body maintaining the strength and structure of bones and teeth, along with certain critical metabolic functions. Genes such as CASR plays a key role in the regulation of serum calcium levels and influences bone mineral density (BMD). Both higher and lower serum calcium levels can have important consequences for health. Individuals with certain genotypes have increased serum calcium levels and several studies have indicated that higher serum levels are associated with an increased risk of cardiovascular disease and suggest the possibility of underlying conditions such as hyperparathyroidism, kidney disease

 
  • Phosphate is a mineral that is necessary for the formation of bones and teeth. In the body, almost all phosphorus is combined with oxygen, forming phosphate. Phosphate is also used as a building block for several important substances, including those used by the cell for energy, cell membranes, and DNA. The body obtains phosphate from the food we eat. Individuals with certain genotypes have decreased serum phosphate levels and therefore have increased requirement.
  • Food sources of phosphate include pumpkin seeds, tofu, beans &lentis and shell fish.
 
  • Magnesium is a mineral, closely associated with skeletal system and cofactor in several important reactions. It is essential for maintaining electrical potential in nerves and muscle membranes. Individuals with certain genotypes have lower serum magnesium levels, therefore have increased requirement.
  • Clinical evidence suggests that the amount of magnesium in urban & western diets is insufficient to meet individual demands and that magnesium deficiency may be contributing to common health problems including diabetes, hypertension, and osteoporosis.
  • Food sources of magnesium include raw spinach, Nuts, Brown rice, Banana, Dark Chocolate.
 

Antioxidants are molecules found in foods like vegetables & fruits, whole cereals, nuts & oil seeds as well as in certain beverages like green tea. They play a key role in reducing the ill-effects of “free radicals” and thereby prevent premature aging, tissue damage and the onset of chronic diseases. Increasing trends in the coffee consumption (90 grams/per capita/per year) suggests these could also be potential contributors of antioxidants in the Indian diet. Individuals with certain genotypes have lower efficiency to defend themselves against free radical damage, they may benefit from an increased intake of antioxidant rich foods.

 

Caffeine is a stimulant found in coffee, tea, chocolate, many soft drinks and energy drinks. Caffeine is a potent vasoconstrictor and makes one feel more alert by increasing blood pressure. However, this stimulant effect can also cause jitters, anxiety, and difficulty sleeping. How quickly an individual metabolizes caffeine has been shown to be influenced by their genotype. Certain genetic variations slow down caffeine metabolism; as a result of which caffeine is retained in the blood for an extended time, increasing the risk for caffeine-associated health disturbances like reduction in bone - mineral density, increased blood pressure and heart ailments.

 

Salt plays an important role in electro-physiological functions of the cell and is essential for nerve and muscle functioning. Cooking salt, which is added for taste enhancement, is the major source of sodium in our diet. According to Global Burden of Diseases (GBD), Injuries and Risk Factors Study, Indians consume about 9.3 grams of salt per day, which is nearly twice the amount recommended by the WHO. High intake of salt is associated with high blood pressure, heart ailments and stroke. Individuals with certain genotypes have been found to be more adversely affected by high salt consumption than others.

 

Gluten sensitivity or intolerance is a condition that causes a person to react after ingesting gluten, a protein found in wheat, barley and rye. Gliadin, a sub-constituent of gluten is slightly strenuous to digest owing to its complex structure, and this becomes a reason for gluten intolerance among 10% of Indians (NIMS, 2014) reacting adversely to wheat or other gluten-rich products. Individuals with certain genotypes have lower tolerances to gluten and exhibit gastrointestinal disturbances like abdominal bloating, cramps and diarrhea. Thus timely detection and adherence to a gluten- free diet can work wonders in managing this digestibility issue

 

Lactose intolerance is one of the most common food intolerances affecting almost 60- 70% of the Indian population, and it is a significant cause of abdominal discomfort to many people. Lactose intolerance occurs when the small intestine does not produce enough lactase —the enzyme that breaks down lactose (milk sugar) into galactose and glucose (simpler units of lactose). An individual’s ability to metabolize lactose is influenced by their genetic makeup. A genetic variation has been to influence lactase enzyme activity and thereby regulate lactose metabolism in adults.